Study on the link of autoimmune hypothyroidism with biochemical parameters and lipid profile in patients with autoimmune thyroid disease

The most prevalent conditions affecting thyroid function were found to be autoimmune thyroidism, like Graves' disease (GD) and Hashimoto's disease (HT). The present study aimed to evaluate biochemical parameters and lipid profile and their correlation with TSH, FT3, and FT4 in patients with HT. The current study recruited 100 individuals (50 HT patients and 50 healthy individuals) aged 18-50 years old during the period from August 2023 to February 2024. Serum levels of TSH, FT3, and FT4 were measured. Moreover, the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoproteins (LDL), glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine were evaluated. Additionally, the correlation of TSH, FT3, and FT4 with lipid profile, liver enzymes, glucose, urea, and creatinine was examined. The present data found that FT3 and FT4 levels were significantly elevated in Hashimoto's illness patients; however, the levels of TSH were greatly reduced in patients with Hashimoto's illness. Moreover, the statistical analysis showed no association between biochemical parameters and lipid profile in TSH, FT3, and FT4. Thus, hypothyroidism could have an indirect effect on biochemical parameters and lipid profile via an indirect path.